Yeh-Chan Ahn, University of California, USA Presentation Title: Optical Sectioning for Microfluidics This keynote paper describes Doppler optical coherence tomography (OCT), a new optical tomographic technique that can image and quantify microstructure and flow simultaneously in microfluidic channel. Doppler OCT is a three-dimensional, non-contact, high-resolution (2-10 µm), real-time imaging technique that provides information of wall location and shape in microchannel, three-dimensional velocity profile, and mixing performance. When Doppler OCT is compared to other techniques for microscale visualization, the uniqueness of Fourier-domain Doppler OCT can be summarized as follows. Fluorescence microscopy (FM) and confocal laser scanning microscopy (CLSM) provide better spatial resolution but cannot measure flow and mixing simultaneously, need transparent liquids and conduits, and give an en face image rather than a cross-sectional image. In contrast to FM, CLSM is able to image different depths but its accessible depth is limited to 0.5 mm. µPIV has been a useful tool for microfluidics, but it is difficult to measure out-of-plane velocity, which is parallel to line-of-sight and is not capable of real-time imaging. A multi-beam Fourier-domain Doppler OCT to be introduced below can quantify a velocity vector with three components without complex postprocessing. In order to enhance spatial resolution of clinical ultrasound, ultrasound biomicroscopy (UBM) with a high-frequency (100-200 MHz) transducer was demonstrated and achieved 15 µm spatial resolution. However, UBM is expensive, has to sacrifice imaging depth in order to enhance spatial resolution, and still needs contact-mode. X-ray is another alternative for microscale visualization. It works with opaque conduits and provides high spatial resolution. Imaging speed, however, is slow, and it needs synchrotron radiation. Doppler OCT can utilize endogenous scattering particle such as red blood cells and works well even in turbid biofluids. It is a promising real-time diagnostic tool for lab-on-a-chips near future. Since the imaging speed is continuously increased by the development of new hardwares such as Fourier-domain mode-lock laser and high-speed line scan camera, it will be possible to measure high transient flow with a speed of several tens centimeters per second. High resolution and high velocity sensitivity of Doppler OCT should find many applications in imaging and quantifying flow dynamics in microchannels such as multi-components, multi-phase, and three-dimensional flows. A brief biography Dr. Yeh-Chan Ahn is a project scientist in Beckman Laser Institute, University of California at Irvine. His research has two prongs: microfluidics and medical endoscopic imaging. He has been trained as a mechanical engineer for 14 years (1989-2003) at POSTECH in Korea, with a focus on measurement techniques for gas-liquid two-phase flow. During his Ph.D. course, he won a fellowship from Korean government and has worked at School of Nuclear Engineering, Purdue University (1999-2000). He developed an advanced electromagnetic flowmetry for two-phase flow for the rest of Ph.D. course. Dr. Ahn also developed an electromagnetic velocity tomography technique for a liquid metal-air two-phase loop as a post-doctoral researcher at POSTECH (2003-2004). In 2004, he won a post-doctoral fellowship from Korean government and joined to Beckman Laser Institute, University of California at Irvine (2004-2007). Beckman Laser Institute is one of the best biophotonic research centers in the world. He is a pioneer who has developed Doppler OCT and applied it to Lab-On-a-Chip (LOC) diagnosis. His work is also focused on developing endoscopic OCT for the detection and diagnosis of cancer during its early and curable stage. He has authored/co-authored 100 papers including 29 refereed journal articles.
	Tobias Bauer, Dresden University of Technology, Germany Presentation Title: Engineering of Reactive Gas/Liquid Two-Phase Flow in Small Channels: A Review Multi-phase flow in combination with equipment miniaturisation is used in an emerging way in process engineering and chemical reaction engineering. The specific properties of microstructure devices make them well suited for mixing, heat and mass transfer, as well as for chemical reactions. In particular, the large surface-to-volume ratio of up to 30,000 m²/m³ and very short diffusion lengths inside the microstructures lead to higher performances in heat and mass transfer compared to conventional chemical devices. This keynote paper presents a state of the art review of research on reactive gas-liquid two-phase flow in small channels with diameters between 50 µm and 5 mm. Special attention is also given to design equations for microstructured chemical reactors with straight flow channels operated in the segmented flow regime. In the past, studies have focused mainly on studying air-water two-phase flow in transparent minichannels and microchannels at ambient temperature and pressure. However, such conditions do not represent process conditions of the chemical industry. Within the framework of a cooperative project, the Technical University of Dresden and the Forschungszentrum Karlsruhe have carried out a broad experimental study in order to obtain detailed data about two-phase flow and chemical reactions in a straight micro channel with a square cross section to further advance the fundamental understanding of gas-liquid two-phase flow and a simultaneous chemical reaction. The results of extensive flow visualization experiments on the adiabatic gas-liquid two-phase flow of industrially relevant gas/liquid fluid pairs varying in density, surface tension and viscosity will be presented. Furthermore, the effect of different gas-liquid feeding systems, such as t-junction and v-shape micro mixer, will also be illustrated. It was found that system pressure (up to 40 bar) and liquid properties have a strong influence on the flow regime boundaries. In the slug flow regime, the liquid properties also influence the gas bubble shape and subsequently the specific mass transfer area, as well as the liquid film thickness between the gas bubble and the wall. Furthermore, the gas-liquid mixing device marginally influences flow pattern boundaries but strongly influences the gas bubble size distribution. The micromixer used created a stable slug flow with a very narrow gas bubble size distribution for low superficial gas and liquid velocities below 0.2 m/s. Furthermore, the gas-liquid two-phase flow in a particle-packed minichannel (dh = 1.0 mm) was visualized and characterized for the first time. The flow patterns found are: slug flow, bubbly slug flow, intermittent dissipated slug flow, continuous dissipated slug flow, intermittent annular flow, annular flow, bubble swarm flow and churn flow. Additionally, various reaction experiments were performed in a palladium-impregnated alumina channel and a catalyst-packed minichannel at elevated pressure and temperature. As test reactions, the hydrogenation of alpha-methylstyrene and the consecutive hydrogenation of cinnamaldehyde were used and the hydrodynamics of the slug flow were measured at the entrance and exit of the reaction channel. The influence of the gas-liquid mixing device, the direction of flow, the catalyst properties, as well as the influence of gas and liquid velocities on space-time yield and selectivity was investigated. The experiments revealed favorable hydrodynamic conditions for high yields and high selectivity. The experimental results on the two-phase flow as well as on chemical reactions are compared to relevant data from the literature. The keynote paper provides the state of the art on the design of microstructured reactors for gas/liquid/solid reactions. A brief biography Dr. Bauer studied Chemical Engineering at the Dresden University of Technology in Dresden, Germany, from 1997 to 2003. From 2002 to 2003 he was research associate at the Washington University in St. Louis in the well-known Chemical Reaction Engineering Laboratory (CREL) under the supervision of Prof. Dudukovic and Prof. Al-Dahhan, working on hydrodynamics of gas-liquid two-phase flow in structured reactors. He received his PhD in Chemical Engineering on the experimental and theoretical investigations of monolithic reactors for three-phase reactions in 2007 from the Dresden University of Technology, under the supervision of Prof. Lange and Prof. Al-Dahhan. For his dissertation he was awarded the Hanns-Hofmann-Preis-2008 of the German DECHEMA e.V., section chemical engineering. He is currently head of the group chemical reaction engineering at TU Dresden, investigating reactive gas-liquid two-phase flow in small channels and structured chemical reactors under industrially relevant conditions.
	Yildiz Bayazitoglu, Rice University, USA Presentation Title: Nanocarpets Decorating the Walls of Microchannels Without the appropriate cooling, the operating temperature of the electronic devices and micro systems could reach values where the components lose their physical integrity, and the proper functioning would cease. In response to this demand, many techniques have been studied and developed such as laser drilled cavities, heat sinks, micro fins, etc. but have still not been able to reach an adequate cooling performance necessary for the components to operate properly. Because of the large heat transfer surface area to volume ratio, microchannels cooling with gas or liquid coolant have been shown to be strong prospects. By lining the walls for the microchannel with nanocarpets in the shape of fins, pins, etc., and based on their size, topology and orientation, they can alter the microchannel thermal performance by enhancing the heat transfer through microstructures. Carbon nanotubes have extremely high thermal conductivities and are excellent candidates to form nanocarpets on other micro or nanostructures. The use of approximated Boltzmann equations, Molecular Dynamics, and Computational Fluid Dynamics to model the heat flow in nanostructured surface microchannels, and the nanotstructure-fluid interface will be reviewed. To reveal the important interactions and to explain the heat transport phenomena, the numerical experimentations related to effect of nanotube length, the nanotube type, the spacing of the nanotubes, and their staggered pattern, and their other physical and material properties in relation to the fluid flow properties within the microchannels will be discussed. A brief biography Professor Yildiz Bayazitoglu is HS Cameron Endowed Chair Professor of Mechanical Engineering in the Department of Mechanical Engineering and Materials Science. Previously, she was assistant professor at the Middle East Technical University in Turkey and was a visiting assistant professor at the University of Houston. She received her B.S. degree in mechanical engineering at the Middle East Technical University, Ankara, Turkey, received her masters and doctoral degrees in mechanical engineering at the University of Michigan, Ann Arbor. Bayazitoglu’s honors include Society of Women Engineers (SWE) Distinguished Educator Award and numerous teaching, mentoring, impact, inventions awards given by Rice University. In 2004 she received the Heat Transfer Memorial Award from American Society of Mechanical Engineers. She is a fellow of the American Society of Mechanical Engineers and associate fellow of the American Institute of Astronautics and Aeronaoutics. Her research interest include the micro scale fluid flow and heat transfer, molecular dynamics, radioactive heat transfer, thermophysical property determination, electromagnetic levitation and melting, nanotube-embedded metals, bio heat transfer and thermal transport in nanostructured materials. She is the editor-in-chief of Americas of the International Journal of Thermal Sciences (IJTS).
	Suman Chakraborty, Indian Institute of Technology / Visiting Stanford University, USA Presentation Title: The Rough Makes It Smooth: Towards Superfluidic Transport in Micro- and Nano-Scale Systems Would you believe that we should design rough surfaces to make them behave in the smoothest possible way? In other words, would you ever imagine that a rough surface may help in inducing a motion on the top of it, instead of inhibiting the same? That, as a possibility, would indeed sound unachievable, until we discovered from our recent study that specially designed tiny water-transport channels (or pores) may achieve this apparently impossible task by two simple mechanisms. First, confining rough surfaces made of water-disliking materials may trigger the formation of tiny bubbles adhering to the walls in tiny channels. This incipient vapor layer acts as an effective smoothening blanket, by disallowing the liquid on the top of it to be directly exposed to the rough surface asperities. In such cases, the liquid is not likely to feel the presence of the wall directly and may smoothly sail over the intervening vapor layer shield. Thus, instead of ‘sticking’ to a rough channel surface, the liquid may effectively ‘slip’ on the same. Secondly, the spontaneous formation of an electrically charged layer adhering to the channel surface, very much typical to such tiny pores, amplifies this tendency of slippage to a large extent, by pumping the layer of fluid even more effectively along with the movable charges. Based on this novel conjecture, we may design miniaturized super-fluidic systems with an unimaginably high rate of liquid pumping, without actually using any pumping device. Key references S. Chakraborty, “Generalization of interfacial electrohydrodynamics in the presence of hydrophobic interactions in narrow fluidic confinements”, Physical Review Letters, vol. 100, pp. 097801(1-4), 2008 S. Chakraborty, “Order parameter modeling of fluid dynamics in narrow confinements subjected to hydrophobic interactions”, Physical Review Letters, vol. 99, pp. 094504(1-4), 2007 S. Chakraborty, “Towards a generalized representation of surface effects on pressure-driven liquid flow in microchannels”, Applied Physics Letters, vol. 90, pp. 034108(1-3), 2007 S. Chakraborty, T. Das, S. Chattoraj, “A generalized model for probing frictional characteristics of pressure-driven liquid microflows”, Journal of Applied Physics, vol. 102, pp. 104907(1-11) A brief biography Dr. Suman Chakraborty has research interests in the area of Microfluidics and Microscale transport processes, including their biomedical / biotechnological, and energy-related applications. He is the central coordinating Professor of the IIT Kharagpur Microfluidics laboratory. He has been a Visiting Professor at the Stanford University (USA), Pennsylvania State University (USA), and a Visiting Scientist at the Aachen University and University of Erlangen (Germany). He is the lead research coordinator and PI of several International collaborations, including those with University of Illinois at Urbana Champaign, University of California at Irvine, Northwestern University, Stanford University, and the University of California at Berkeley in the USA, as well as with the University of Tokyo/ Tokai University in Japan, in the areas of Microfluidics and Nanofluidics. He has been elected as the youngest Fellow of the Indian National Academy of Engineering (FNAE). He has been the recipient of the Swarnajayanti Award, Indo-US Research Fellowship, and Young Scientist/ Young Engineer Award from all National Academies of Science and Engineering. He has also been an Alexander von Humboldt Fellow. He has delivered invited Lectures in several Conferences and special events of National and International importance, including a special Lecture for the Mathematical Physics Colloquium at MIT, USA. He has 125+ International Journal publications, including papers in the Physical Review Letters, Applied Physics Letters, Physical Review E, Langmuir, Lab ob a Chip, Journal of Applied Physics, Journal of Fluid Mechanics, Physics of Fluids etc. More detailed information on his work and recent innovations can be found at http://www.stanford.edu/~sumancha/.
	Hsueh-Chia Chang, University of Notre Dame, USA Presentation Title: Electrokinetics in Nanochannels: The Next Generation of Molecular and Chemical Sensors Because nanochannels act as lenses that can focus electric fields on a chip, they can concentrate and trap molecules, ions and nanocolloids by electrodeless dielectrophoresis (DEP). With functionalized molecular/ion probes at the entrance or within the channel and with AC fields of specific frequency, selective trapping and concentration can also be achieved, much like ion-channels on cell membranes. We review some of these nanochannel sensor technologies from our laboratory. In particular, we scrutinize the nonlinear I-V characteristics and impedance spectra of the nanochannel sensors, as a means of detecting the selectively trapped targets, and explore the underlying polarization, electrokinetic and hydrodynamic phenomena. A brief biography Professor Hsueh-Chia Chang is a leading researcher on chip-scale technologies based on electrokinetics. His inventions include genetic nanocolloid dielectrophoresis, high-pressure DC electro- osmotic silica monolith pump, AC spray mass spectrometry, nanoporous dynamic concentrator etc. He is the Bayer Professor of Engineering at the University of Notre Dame and is also the director of the Center for Microfluidics and Medical Diagnostics there. He is the founding editor-in-chief of Biomicrofluidics (http:bmf.aip.org), an American Institute of Physics journal. He is a fellow of the American Physical Society and won its Frenkiel Award in hydrodynamics in 1991. His book "Non-equilibrium and Nonlinear Electrokinetics" will be published by Cambridge University Press in 2009. Prof Chang grew up in diaspora Chinese communities in Taiwan, Singapore, Malaysia and southern California. His former PhD and post-doc students now hold faculty positions at Missouri, UC San Diego, Wuhan, Monash, Mississippi State, Tennessee, Florida, Rutgers, Michigan Tech, Imperial College, Howard, Tunghai, Chong Cheng, Cheng Kung.
	Hyung-Hee Cho, Yonsei University, Korea Presentation Title: Flooding Visualization and Improved Water Management in Pem Fuel Cell Internal water management in proton exchange membrane (PEM) fuel cell has been considered as one of most significant key factors for its performance enhancement. It is because relative humidity of hydrogen and air is strongly related to the performance of PEM fuel cell in terms of H+ movement within the membrane. In addition, production of H2O by chemical reactions can bring various problems during concentration loss region since combination of vapor in supplying air and byproduct of chemical reaction should lead to excess H2O remaining in PEM fuel cell, resulting flooding phenomena which may block air flow channels. Therefore, in order to understand and manage such phenomena to enhance the performance of PEM fuel cell, especially under concentration loss region, this lecture focuses on the visualization of the flooding phenomena and application of the modified flow path on the cathode separator for flooding reduction. Key-Words: PEM Fuel Cell, Flooding, Water Management, Visualization, Performance Enhancement A brief biography Professor Hyung Hee Cho received the B.S. (1982) and M.S. (1985) degrees in mechanical engineering from Seoul National University, Korea and the Ph.D. degree (1992) from University of Minnesota, USA. He has been the faculty of Department of Mechanical Engineering, Yonsei University, Seoul, Korea since 1995. He has served for a chairman of Department of ME and an associate dean of College of Engineering, Yonsei University. His research interests include heat transfer and flow control/design in energy systems such as turbomachineries as well as PEM fuel cells. For turbomachineries, he has accomplished major research achievements of various cooling techniques, such as film cooling, internal passage cooling and impingement/effusion cooling. For PEM fuel cells, he has been working on flooding management and visualization by controlling flow characteristics and heat transfer of PEM fuel cell separator. He has published more than 150 papers in journals, about 200 papers in conference presentations/proceedings, and more than 15 patents. He is currently vice president of KSME Energy and Power Division, a committee member of Gas Turbine Heat Transfer Committee (ASME), a scientific council member of International Center for Heat and Mass Transfer (ICHMT), and in editorial board of three international journals; JP Journal of Heat and Mass Transfer, Advances in Mechanical Engineering and International Journal of Fluid Machinery and Systems.
	Andreas Freidrich, Institute of Technical Thermodynamics, Germany Presentation Title: Fuel Cells for Aircraft Application Although air transport is responsible for only about 2 % of all anthropogenic CO2 emissions, the rapidly increasing volume of air traffic leads to a general concern about the environmental impact of aircrafts. Future aircraft generations have to face enhanced requirements concerning productivity, environmental compatibility and higher operational availability, thus effecting technical, operational and economical aspects of in-flight and on-ground power generation systems. Today’s development in aircraft architecture undergoes a trend to a “more electric aircraft” which is characterised by a higher proportion of electrical systems substituting hydraulically or pneumatically driven components, and, thus, increasing the amount of electrical power. Fuel cell systems in this context represent a promising solution regarding the enhancement of the energy efficiency for both cruise and ground operations. For several years the Institute of Technical Thermodynamics of the German Aerospace Center (Deutsches Zentrum für Luft- und Raumfahrt, DLR) in Stuttgart is engaged in the development of fuel cell systems for aircraft applications. The activities of DLR focus on: Identification of fuel cell applications in aircraft in which the properties of fuel cell systems, namely high electric efficiency, low emissions and silent operation, are capitalized for the airplane application. Design and modeling of possible system designs. Experimental investigations regarding specific aircraft relevant operating conditions. Qualification of airworthy fuel cell systems. Set up and full scale testing of fuel cell systems for application in research aircraft. In cooperation with Airbus several fuel cell applications within the aircraft for both ground and cruise operation could be identified. In consequence fuel cell systems capable to support or even replace existing systems were derived. In this context, kerosene tank inertization and electrical cabin power supply including water regeneration represent the most promising application fields. The contribution will present the state of development discussing the following points: Modeling of different system architectures and evaluation of promising fuel cell technologies (PEFC vs. SOFC). Experimental evaluation of fuel cell systems under relevant conditions (low-pressure, vibrations, reformate operation, etc.). Fuel cell system demonstrator Hyfish (hydrogen powered model aircraft) Fuel cell test in DLR`s research aircraft ATRA (A320) including the test of an emergency system based on hydrogen and oxygen with 20 Kilo Watts (kW) of electrical power. A brief biography Dr. K. Andreas Friedrich is a Professor of Mechanical Engineering at University of Stuttgart and the Head of the Fuel Cell Research group at the German Aerospace Center (DLR) in Stuttgart, Germany. His research areas include the development of Polymer Electrolyte Fuel Cells as well as Solid Oxide Fuel Cells. The primary goals comprise enhanced power density, long lifetime, reduction of materials and manufacturing costs, identification of degradation mechanisms in stacks and their prevention, advanced stack design, highly integrated system components and optimised integration of fuel cells into energy supply systems. The development of fuel cell systems for aircraft applications at DLR has recently received the f-cell award in silver. Dr. Friedrich has published more than 90 research papers, co-authored three books and co-edited two conference special issues.
	Kohei Ito, Kyushu University, Japan Presentation Title: In-Situ Measurement in Through-Plane Direction in PEMFC PEMFC (Polymer Electrolyte Membrane Fuel Cell) consists of micro-porous membranes, and it generates electricity, accompanying mass and charge transports through the membrane. From the mechanical engineering point of view, there is an issue to establish water management. According to a given water management, we have to suppress the drying-up in PEM (Polymer Electrolyte Membrane) and the flooding in GDL (Gas Diffusion Layer), which degrade the performance of PEMFC. To give a proper water management, it is necessary to understand the water distribution in PEMFC. Temperature distribution, which develops in the cell and gives some impacts on the water distribution, is also significant information that we should know in advance. The water and temperature distribution in PEMFC develop in any direction: in-plane and through-plane direction. Among them the through-plane direction has major role, because the transport of mass, heat and electric charge mainly progress in this direction. Thus it is expected to develop the tools to measure the distribution in the through-plane direction. Against for this background, this key note lecture briefly shows our through-plane measurement results, which were obtained with the three tools: cross sectional cell, micro-TC (Thermo-Couple) and micro-coil. With the method of the cross sectional cell devised, we visualized the water behavior in cathode cross section. The separator of this cell has unique geometry, leading to successfully capturing the behavior of water droplet, which emerged at catalyst layer and spread in GDL toward flow channel. It was understood that the faster rate of air supply in cathode flow channel inhibited the growth of water droplet in cathode GDL. In the method of the micro-TC, we placed seven micro-TCs in array in a cell, and succeeded in measuring the temperature distribution in through-plane direction, giving little impact of the micro-TC on performance of the cell. Under the steady state condition for the load current of 0.6A/cm2, the temperature of cathode catalyst layer was highest in the cell, and it was 0.7 K higher than that of anode catalyst layer. In the transient state just after stopping the load current, the temperature of cathode catalyst layer had minimum. These temperature distributions were well explained by the endothermic and exothermic distribution in the cell. In the method of the micro-coil, we measured the water content distribution in PEM with placing it in a cell, similar way to the case of micro-TC. The micro-coil works as NMR sensor, and the NMR signal intensity obtained from it corresponds to the local water content near the coil. The water content in both anode and cathode side dynamically changed with the step-wise increase of load current. However, the trend of them was largely different. This difference was caused by the water transport mechanics in PEM such as electro-osmosis drag. A brief biography In 1996, Kohei Ito obtained his Dr. Eng. from the Tokyo Institute of Technology, where he was engaged in the study of nano/micro scale heat/electric transport, as a JSPS researcher. From 1996 to 2003, he worked as a research assistant and partially as a WE-NET project researcher in Toyohashi University of Technology. During this time he was engaged in experiment and numerical simulation for secondary batteries, fuel cells and water electrolysis cells, aiming at better water/thermal management of these electrochemical devices. He was also involved in applications of plasma technology, such as pulsed-discharge de-nitrification. From 2003, he has as an associate professor in the Department of Mechanical Engineering Science, Kyushu University. His current interest is to develop new diagnostic tools for fuel cell and water electrolysis cell, and to give mathematical models on these electro-chemical processes. He has joined two national research projects: ‘High-pressure water electrolysis hydrogen station’ (2004-2005) and ‘Hydrogenius’ (2006-2012). In the latter project he challenges to measure hydrogen solubility in water under high pressure condition. So far he succeeded in obtaining the data up to 30 MPa.
	Ygendra Joshi, Georgia Tech, USA Presentation Title: Thermal Characterization of Interlayer Microfluidic Cooling of Three-Dimensional Integrated Circuits with Non-Uniform Heat Flux It is now widely recognized that three-dimensional (3D) system integration is a key enabling technology to achieve the processing speeds and performance needs of future integrated circuits (ICs). To provide modular thermal management in 3D stacked ICs, interlayer microfluidic cooling scheme is adopted and analyzed in this study. The effects of essential geometry variations are quantitatively analyzed on the routing completion and congestion of electrical signal carrying interconnects. Also, the thermal and hydraulic performance of several two-phase refrigerants is discussed in comparison with single-phase cooling. The results show that refrigerants in two-phase flow are thermally preferred due to the higher heat transfer coefficients, and relatively constant fluid temperature through the microchannel. However, the large interior pressure and pressure drop act as significant limiting factors in realizing their merits. It is also concluded that proper hot-spot thermal management is key to addressing mass flow rate mal-distribution. Keywords: microchannel, microfluidic cooling, three-dimensional IC, non-uniform heat flux, single-phase, two-phase, pressure drop A brief biography Yogendra Joshi is Professor and John M. McKenney and Warren D. Shiver Distinguished Chair at the G.W. Woodruff School of Mechanical Engineering at the Georgia Institute of Technology. He directs the Microelectronics and Emerging Technologies Thermal Laboratory (METTL), as well as the Consortium for Energy Efficient Thermal Management (CEETHERM). He is an elected Fellow of the ASME and the American Association for the Advancement of Science. He has served as Associate Editor for the ASME J. of Electronics Packaging for two terms and Associate Editor for the ASME J. Heat Transfer. He was a co-recipient of ASME Curriculum Innovation Award (1999), Inventor Recognition Award from the Semiconductor Research Corporation (2001, 2007), ASME Electronic and Photonic Packaging Division Outstanding Contribution Award in Thermal Management (2006), and IBM Faculty Award (2008). He is the author or co-author of over two hundred publications, including over one hundred archival journal articles. His interests are in multi-scale thermal management of hybrid microsystems.
	Kwan-Hyoung Kang, POSTECH, Korea Presentation Title: Hydrodynamic Flows in Electrowetting The electrical control of wettability, which is called the electrowetting, is a versatile tool for handling of micro- and nano-liter drops. The electrowetting can be used as a very fast and efficient means to handle nearly any kind of drops with a relatively low electrical potential and power consumption. In the first part of the talk, I will present the hydrodynamic flows generated inside a droplet in electrowetting when an ac voltage is applied. In order to find out the characteristics and origin of the flows, we investigated the flow pattern for a sessile droplet for various conditions. A shape oscillation of a droplet was observed in the low-frequency range by a high-speed camera. The shape oscillation is responsible for the low-frequency flow. The flow at high frequency is caused by some electrohydrodynamic effect. In the second part of the talk, an experimental and theoretical work will be presented concerning the shape oscillation of sessile droplet. A set of shape mode equations is derived to describe unsteady motions of a sessile drop actuated by electrowetting. A unified boundary condition is obtained, which is valid at the three-phase contact line as well as the drop surface, by combining the equation for dynamic contact angle and the normal stress condition. The equilibrium contact angle of electrowetting predicted by present method shows a good agreement with those of Lippmann-Young equation and our experiments. The present theoretical model is also validated by predicting the spreading process of a droplet for step input voltages. It shows a qualitative agreement with experimental results in temporal evolution of drop shape. Finally, I will present a novel method to actuate oscillation of a sessile bubble or oil drop in a fluid to produce steady streaming within the fluid. This method is based on time-periodic control of the wettability of the bubble or drop by electrowetting. Jet velocity is proportional to oscillation amplitude and is greatest at natural oscillation frequencies. Analytical and numerical analyses indicate that the jet is produced by steady streaming in the Stokes layer. A brief biography Kwan Hyoung Kang is an Assistant Professor of Department of Mechanical Engineering at Pohang University of Science and Technology (POSTECH). He works in the microfluidics field with a particular interest in electrical control of microscale fluids and particles including electrowetting, dielectrophoresis, electrokinetics, and electrohydrodynamics. He developed an electromechanical theory of electrowetting and found out the origin of electrowetting phenomenon. He found hydrodynamic flows in ac electrowetting including a synthetic jet produced by an oscillating sessile droplet. He discovered an electrohydrodynamic flow produced by nonuniform electric fields in dielectric liquids. His laboratory has been assigned as one of the National Research Laboratory (NRL) by the Korean government with the title of “Electro-Microfluidics Lab” since year 2007. The project is entitled “Development of an electromechanics-based multi-functional microfluidic platform for handling of microscale fluids and particles.” Ongoing project includes investigations on the switching speeds of electrowetting-based switches and electrophoresis-based electric papers. Prof. Kang received his PhD, MS, and BS in Mechanical Engineering from the POSTECH in 1996, 1993, and 1991, respectively.
	Jungho Kim, University of Maryland, USA Presentation Title: Nucleate Pool Boiling Heat Transfer: The Real Bubble Heat Transfer Mechanisms Many conflicting mechanisms and models of bubble heat transfer have been proposed over the years. The inability to resolve the differences was primarily due to difficulties in obtaining the time and space resolved information needed to verify the models. Recent high resolution heat flux measurements by independent researchers using a variety of techniques along with advances in numerical simulations of boiling have resulted in a much clearer understanding of the important bubble heat transfer mechanisms. Similar mechanisms were observed for constant wall temperature and constant wall heat flux boundary conditions, saturated or subcooled flows, and for a variety of fluids. In this paper, the proposed heat transfer mechanisms are reviewed and the recent experimental and numerical results along with their implications are discussed. A brief biography Professor Kim is currently Professor of Mechanical Engineering at the University of Maryland. He received his BSME from the University of California, Berkeley (1982), and his MSME (1986) and Ph.D (1990) from the University of Minnesota. He worked at Arvin/Calspan Corporation in Buffalo, NY between 1990-1992 where he performed research in gas turbine heat transfer. He joined the University of Denver in 1992, and has been at the University of Maryland since 1998. His current research interests are boiling and spray cooling heat transfer, radiation absorption measurements of fuels at high temperatures, emissivity measurements, inverse heat conduction methods, and instrumentation. He has published over 100 technical papers and is the holder of two patents.
	Dong-Pyo Kim, Chungnam National University, Korea Presentation Title: Novel Inorganic Polymer Derived Microfluidic Devices: Materials, Fabrication, Microchemical Performance Microreaction at lab-on-a chip system has been successfully used in analytical chemistry and bio-applications. In these applications, the devices have been generally fabricated with durable glass, Si and metal by expensive MEMS fabrication, alternatively with PDMS and other plastics which have excellent processibility via soft lithography techniques but low stability in organic solvents. Therefore, it must be demanded to develop the novel materials based microfluidics with high stability by facile fabrication process. Firstly, we introduce the successful fabrication of inorganic polymer derived microchannels with organic solvent resistance and optical transparency, via economic micro-molding process by using two types of source materials: commercial polyvinylsilazane (HTT1800 Kion Corp.), or allylhydropolycarbosilane (SMP-10, Starfire Co.). And we demonstrated the reliable microchemical performance in various organic solvents such as THF, DMF and acetonitrile at elevated temperatures. Knovenagel and Diels-Alder reactions were successfully run by pressured-driven flow in 2 cm and 16 cm long channel, respectively. And also, photochemical catalytic decomposition of 4-chlorophenol in the presence of TiO2 nanoparticle was compared with the performance of glass based microreactor. In particular, the chiral compounds of (R)- and (S)-Ibuprofen were separated in a triple laminar flow with ionic liquid membrane. At the second part, we present the fabrication and characterization of ceramic microreactors composed of inverted beaded silicon carbide (SiC) monoliths with interconnected 0.75-, 2.2-, or 7.2-µm pores as catalyst supports, integrated within high-density alumina reactor housings obtained via an optimized gel-casting procedure. These tailored macroporous SiC porous monoliths deposited Ru as the catalyst was run for the decomposition of ammonia with at temperatures between 450 and 1000°C, which demonstrated a high temperature fuel cell reformer. Finally, it is proven that the developed inorganic polymer-based microchannels were obviously performed as a niche material-based microfluidic device between plastic and glass based device. In the future, it can be novel promising platforms by combining with top-down approach in microchemistry as well as biotechnology for unique integrated microfluidic device.
	Michael King, Cornell University, USA Presentation Title: Flow-Based Devices for the Adhesive Capture and Reprogramming of Circulating Tumor Cells Invasive cancer cells detach and migrate to new sites to initiate de novo tumors via the bloodstream, into which typically ~106 cells are released per gram of tumor tissue per day. The number of these circulating tumor cells (CTC) ranges based on the patient and stage of disease but is usually on the order of 1- 10 cells/mL. We have designed a microscale flow system that targets surface receptors on CTC to selectively capture the cells from whole blood samples. Using KG1a human leukemia cells we have shown that we can capture cancer cells from whole blood at clinically relevant concentrations. Interestingly, nanoparticle coatings are found to significantly increase the effectiveness of cell capture. Our system can be modified to capture CTC of both blood and epithelial origin and a novel characteristic is that intact, viable cells are obtained. We propose that these cells can be used to screen patients for tumors as well as test for remission. Additionally, the efficacy of chemotherapy and targeted therapies can be tested on CTC isolated from individual patients. Our results indicate that this device could be a powerful new tool in the clinical detection and treatment of cancer. Another project in our laboratory is focused on the co-immobilization of an apoptosis ligand along with adhesion proteins on the microdevice surface, to neutralize circulating tumor cells in the bloodstream. This new approach is intended to filter the bloodstream and actively prevent the formation of hematologic metastases, and has been successfully demonstrated in vitro. A brief biography Michael King is an Associate Professor of Biomedical Engineering at Cornell University, after six years on the faculties of Biomedical Engineering and Chemical Engineering at the University of Rochester. King received a B.S. degree from the University of Rochester and a Ph.D. from the University of Notre Dame, both in chemical engineering. He was an NIH/NRSA postdoctoral fellow in Bioengineering at the University of Pennsylvania. King is a former Whitaker Investigator, a James D. Watson Investigator of New York State, an NSF CAREER Award recipient, and the scientific founder of CellTraffix, Inc. King received the 2008 ICNMM Outstanding Researcher Award from the American Society of Mechanical Engineers, and was the 2007-2008 Professor of the Year in Engineering at the University of Rochester. He is the co-author of two books published by Elsevier, 48 journal articles, and his research interests include biofluid mechanics and cell adhesion.
	Isao Kobayashi, National Food Research Institute, Japan Presentation Title: Microchannel Emulsification Devices for Generating Highly Uniform Droplets Monodisperse emulsions consisting of uniform droplets have received a great deal of attentions over the past decade due to their high-tech applications, e.g., monodisperse microparticles as spacers for electronic devices and monodisperse micro-carriers for drug delivery systems (DDS). Our group proposed microchannel (MC) emulsification in the mid 1990s, in which highly uniform droplets with coefficients of variation of less than 5% can be generated using MC arrays with a slit-like terrace. The resultant droplet size can be precisely controlled by MC geometry. Droplet generation for MC emulsification is very mild and does not require any external shear stress; a to-be-dispersed phase that passed through MCs is transformed spontaneously into uniform droplets inside a continuous-phase domain. This paper presents recent developments in MC emulsification devices, particularly focusing on straight-through MC arrays consisting of uniform straight-through holes for large-scale production of monodisperse emulsions. This paper also gives some examples of numerical studies on MC emulsification using computational fluid dynamics (CFD). A brief biography Isao Kobayashi received his degrees of B.E. (1998) and M.E. (2000) in Industrial Chemistry from Tokyo University of Science, and his Ph.D. degree (2003) in Agricultural Science from University of Tsukuba for a thesis entitled ‘Development and characterization of microchannel emulsification devices for monodisperse emulsions’. He had been a JSPS postdoctoral research fellow at Graduate School of Life and Environmental Sciences, University of Tsukuba from 2003 to 2005. He has worked at Food Engineering Division, National Food Research Institute since fall 2005. He has authored and co-authored approximately 40 archival journal papers and two book chapters in edited volumes. He is a recipient of the 49th Best Paper Award for Oil & Fats Technology in 2006 (presented by Foundation, Oil & Fats Industry Kaikan) and the Japanese Society for Food Science and Technology Award for Best Paper of the journal ‘Food Science and Technology Research’ in 2008. His current research area includes two-phase applications of microchannel arrays and nanochannel arrays, especially for producing monodisperse emulsions and their applications.
	Norbert Kockmann, Lonza Ltd., Switzerland Presentation Title: Transitional Flow and Related Transport Phenomena in Complex Microchannels Microchannels are research objects since decades concerning flow characteristics, heat and mass transfer, mixing and chemical reactions inside. The major focus is given to simple inlet and contacting geometries and straight channels with laminar flow. These microstructured devices offer unique transport capabilities for rapid mixing, enhanced heat and mass transfer and can safely handle dangerous or unstable materials. Hence, there is besides research investigations a profound industrial interest such as rapid synthesis of new chemical entities, chemical process design with facile scale-up, and large scale production of organic chemicals. The involved microstructured devices must deal with flow rates from few microliters/minute to hundreds of milliliters/minute from pressure driven flow resulting in Reynolds numbers from unity to several thousands. Low Reynolds number flow is governed by fluid viscosity and provides low transfer capabilities, especially for liquid flow. To enhance heat and mass transfer as well as fluid mixing, the channel geometry is varied to induce secondary flow phenomena and vortices. To these variations belong wall corrugations, zigzag or meandering channels as well as fluidic contacting elements with curved flow such as T-shaped or tangential flow junctions. The flow regimes in such elements are only rudimentary characterized over the wide range of relevant Reynolds numbers. One exception is the convective flow in T-shaped micromixers with symmetric inlet conditions, which start from straight laminar flow (Re < 10) over the first appearance of a double vortex pair (Re<140), then engulfment flow (140 < Re < 240) and the first appearance of periodic pulsations (240 < Re < 350) to chaotic flow pulsations (Re> 400) [1]. The flow regime determines the mixing process in the T-shaped micromixer, related chemical reactions, and particle precipitation. Similar development of flow regimes can be observed in other microchannel arrangements. The understanding of the flow structures is important for the performance of microstructured devices and their design and application [2]. The keynote presentation will give an overview and figure out research needs for further development and application of micromixers for chemical synthesis and large scale production. Simple and combined elements of microchannels are presented concerning their flow characteristics and related mixing and heat and mass transfer characteristics. The profound understanding of the transitional flow regime with Reynolds numbers from 100 to several thousands is necessary for proper design and successful application. Here, basic research is needed for simple channel structures and their combinations concerning flow rgimes and related transport phenomena. Recent applications of microreactors at Lonza Ltd. are described with high flow rates for the production of pharmaceuticals. The convective flow and related transport phenomena are essential for the successful application of microstructured devices in fine-chemical and pharmaceutical production. [1] N. Kockmann, Transport Phenomena in Micro Process Engineering, Springer, Berlin, 2008. [2] N. Kockmann, M. Gottsponer, B. Zimmermann, D.M. Roberge, Enabling Continuous-Flow Chemistry in Microstructured Devices for Pharmaceutical and Fine-Chemical Production, Chem. Europ. J. 14, 7470-7477, 2008. A brief biography Dr. Norbert Kockmann received his diploma degree in mechanical engineering in 1991 from the Technical University of Munich and went to University of Bremen. Here, he finished his dissertation on fouling problems in evaporation in 1996. For almost five years, he worked as project manager at Messer Griesheim, Krefeld, for design, construction, and operation of air separation units and a syngas plant. In 2001, he joined Institute of Microsystems Engineering - IMTEK, University of Freiburg, as group leader of micro process engineering. He is editor and author of two monographs on micro process engineering and several journal papers. In 2007, Norbert Kockmann finished his habilitation thesis and started as research associate at Lonza Ltd., Switzerland, responsible for microreactors and continuous reaction technology.
	Sungho Lee, Hyundai Motor Company, USA Presentation Title: Water Management in PEMFC Stack of Hyundai FCEV The PEMFC (Polymer Electrolyte Membrane Fuel Cell) requires well hydration for acceptable protonic conductivity, but liquid water in the catalyst layers and gas diffusion layers can cause performance loss due to blockage of reactants to the catalysts. Many activities have been done on the water management in PEMFC stack to guaranty better performance and its longevity. Some approaches for PEMFC stack in Hyundai-motor will be shown in this presentation based on analytic modeling, CFD, and experiment. A brief biography I’m a senior research engineer at Hyundai motors and working on Fuel cell analysis. I received my Ph.D. in Mechanical engineering from University of Southern California (2004), and the thesis is ‘Analysis Of Thermocapillary Flows In Flattened Laser-Heated Glycerin Drop Levitated by Acoustic Pressure’. It is related on temperature driven flow in sub milimeter drop and external flow layer around the acoustically levitated drop conducted by acoustic wave. My research area in Hyundai motors is about PEMFC analysis, especially, heat & mass transfer in a stack. Recently, water behavior in fuel cell has been studied by experiments and analytic models on gas channel and porous media.
	Qiao Lin, Columbia University, USA Presentation Title: An Aptamer-Functionalized Microfluidic Platform for Biomolecular Purification and Sensing Aptamers are oligonucleotides (DNA or RNA) that bind to chemical and biological analyte targets via affinity interactions. Through an in vitro synthetic process, aptamers can be developed for an extremely broad spectrum of analytes, such as small molecules, proteins, cells, viruses, and bacteria. Target recognition by aptamers is highly selective, as affinity interactions result in secondary aptamer conformational structures that specifically fit the target. The aptamer-target binding is also reversible and depends strongly on external stimuli such as pH and temperature. The specificity and stimuli-responsiveness of aptamers are highly attractive to biological purification and sensing, which generally involve isolating minute quantities of targets from complex samples with non-specific molecules and impurities present at orders-of-magnitude higher concentrations. We present an aptamer-functionalized microfluidic platform that by design exploits the specificity and temperature-dependent reversibility of aptamers to enable biomolecular purification and sensing. Using the specificity of aptamers, we demonstrate highly selective capture and enrichment of biomolecules. Employing thermally induced, reversible disruption of aptamer-target binding, we accomplish isocratic elution of the captured analytes and regeneration of the aptamer surfaces, thereby eliminating the use of potentially harsh reagents. Using integrated microfluidic control, the eluted analytes are detected in a label-free fashion by mass spectrometric methods. A brief biography Qiao Lin is an Associate Professor of Mechanical Engineering at Columbia University, and the Director of the Columbia Biofluidic Microsystems Laboratory. Dr. Lin’s research centers on microelectromechanical systems (MEMS) as applied to biological sensing and manipulation, emphasizing integration of MEMS transducers with microfluidics for label-free characterization and manipulation of biomolecules. His current efforts primarily involve exploiting stimuli responsive polymers for biomolecular manipulation and label-free detection, creating integrated microsensors for measuring thermodynamic behavior of biomolecules, devising implantable MEMS sensors for continuous glucose monitoring, and developing efficient and accurate models to facilitate understanding and design of biomedical MEMS devices.
	Jing Liu, Tsinghua University, China Presentation Title: Cryogenic and Fluidic Ways Lead to Low Cost Micro/Nano Devices Building systems as compactly as possible has been a major theme in many current science and engineering fields. However, such enthusiastic endeavor often encounters big troubles due to high cost and complexity of the process it involves. Part of the reasons comes from the methodology itself, and the fabrication, designing and characterization procedure etc. Among various disciplines to making micro/nano object, those enabled from the thermal and hydrodynamic science plays a rather important role. In this talk, I will outline a cryogenic technique for realizing a group of different micro/nano devices which can be implemented as mechanical, hydraulic, electrical, or optical functional units. The basic principle of this method is based on the formation of ice crystals, from which micro/nano aqueous objects or signals transmitting across them can easily be blocked, manipulated and analyzed. In this way, a series of micro/nano devices such as freeze tweezer, ice valve, freeze-thaw pump, electrical or optical signal switch and micro thermal analyzer etc. can be developed via a rather simple and low cost way. As examples, some latest advancement made in the author’s lab will be illustrated. Their innovative applications in a wide variety of micro/nano engineering fields will be discussed. Further, to illustrate the low cost way to directly manufacture micro/nano objects, I will explain a bubble fabrication method whose basic principle lies in the chemical reaction occurring at the fluidic interfaces between two or more soap bubbles. A unique virtue of the bubble is that it can have a rather large diameter however an extremely small membrane thickness, whose smallest size even reaches nano scale. Therefore, the administrated chemical reaction in the common boundary of the contacting bubbles would lead to products with extremely small size. Particularly, all these were achieved via a rather straightforward way. The bubble builds up a bridge between the macroscopic manipulation/observation and the fabrication in small world. Several typical micro structures as fabricated in our lab will be illustrated. As a flexible, easily controllable, and low cost method, the bubble fabrication can possibly be developed as a routine strategy for making micro/nano structures in the near future. A brief biography Dr. Jing Liu is a Professor in the Department of Biomedical Engineering at Tsinghua University and a Guest Professor at the Technical Institute of Physics and Chemistry, the Chinese Academy of Sciences (CAS). He received his B.E. in turbomachinery, B.S. in Physics in 1992, and Ph.D. in thermal science in 1996, all from Tsinghua University. He is an author of 6 popular Chinese books (among which the Micro/Nano Scale Heat Transfer published in 2001 has already been pressed 4 times so far), 10 invited book chapters and over one hundred peer reviewed journal papers, and holds more than 80 China Patents. His work has led to several conceptual innovations such as liquid metal based computer cooling, nano-cryosurgery, the hybrid cryosurgical/hyperthermia system for targeted tumor treatment, as well as interventional whole body hyperthermia medical equipment etc. Dr. Liu is a recipient of the National Science Fund for Distinguished Young Scholars of China, National Science and Technology Award for Chinese Young Scientist, and 4 times highest Teaching Awards from the CAS. His current research interests include: micro/nano fluidics, bioheat and mass transfer, nano medicine, chip cooling, and medical microsystem technology. More information can be found at www.bioheat.ac.cn.
	Partha Mukherjee, Los Alamos National Laboratory, USA Presentation Title: Capillarity, Wettability and Interfacial Dynamics in Polymer Electrolyte Fuel Cells In the present scenario of a global initiative toward a sustainable energy future, the polymer electrolyte fuel cell (PEFC) has emerged as one of the most promising alternative energy conversion devices for different applications. Despite tremendous progress in recent years, a pivotal performance/durability limitation in the PEFC arises from liquid water transport, perceived as the Holy Grail in PEFC operation. The porous catalyst layer (CL), fibrous gas diffusion layer (GDL) and flow channels play a crucial role in the overall PEFC performance due to the transport limitation in the presence of liquid water and flooding phenomena. Although significant research, both theoretical and experimental, has been performed, there is serious paucity of fundamental understanding regarding the underlying structure-transport-performance interplay in the PEFC. The inherent complex morphologies, micro-scale transport physics involving coupled multiphase, multicomponent, electrochemically reactive phenomena and interfacial interactions in the constituent components pose a formidable challenge. In this talk, the impact of capillary transport, wetting characteristics and interfacial dynamics on liquid water transport will be presented based on a comprehensive mesoscopic modeling framework with the objective to gain insight into the underlying electrodics, two-phase dynamics and the intricate structure-transport-interface interactions in the PEFC. A brief biography Partha P. Mukherjee received his Ph.D. in Mechanical Engineering from Pennsylvania State University (PSU) in 2007. He holds a B.S. degree (1997) from University of North Bengal, India and a M.S. degree (1999) from Indian Institute of Technology – Kanpur, India, both in Mechanical Engineering. He worked as a consulting engineer for four years in Fluent India Pvt. Ltd, a fully owned subsidiary of Ansys – Fluent, USA, prior to joining PSU in August, 2003. He joined Los Alamos National Laboratory (LANL) in 2008. His research interests include transport and materials aspects of electrochemical energy systems, multiphase/multicomponent/reactive transport in porous media, pore-scale modeling and virtual materials design.
	Mamoru Ozawa, Kansai University, Japan Presentation Title: Flow Boiling of Carbon Dioxide in Horizontal Mini-Channels and Pattern Dynamics Approach to Study Flow Pattern Increasing attention has been focused on carbon-dioxide (CO2) heat pump system where the temperature level is rather low, while the operating pressure is rather high. In this system the density difference between vapor and liquid becomes rather small, which significantly affects flow patterns. Low surface tension and latent heat also have significant influence on two-phase flow patterns and heat transfer. This paper describes experimental and numerical investigation on flow patterns and heat transfer characteristics of flow boiling of CO2 at high pressure in horizontal small-bore tubes ranging from 0.51mm to 3.0 mm I.D. Even though the density difference is rather small at high pressure, phase stratification takes place in tubes with 1-3 mm in diameter. This leads to intermittent dryout at the upper wall. So far the discrete bubble model developed previously by the authors for vertical flows is modified to include horizontal flow mechanisms. The predicted flow patterns with this new model agree on the whole with the experimental observations. A brief biography Professor Mamoru Ozawa received M. Eng. degree from Kobe University in 1974 and D. Eng. degree from Osaka University in 1977. Throughout his graduate courses in Kobe and Osaka Universities, he focused his research interest on boiling heat transfer and two-phase flow dynamics. He carried out his research activity in various universities, starting from Osaka University, Kobe University, and University of Karlsruhe in Germany to Kansai University. Throughout his carrier, he expanded his research fields to include a variety of thermal engineering problems. He has been a professor in the Department of Mechanical Engineering, Kansai University since 1994. His current research includes boiling heat transfer, two-phase flow dynamics, fluidized bed, natural and forced convection heat transfer, and combustion. He was a member of organizing committee of ICMF'04, a founding member of UK-Japan Seminar on Multiphase Flow, an organizer of German-Japanese Seminar on Two-Phase Flow, a member of the board of directors of Heat Transfer Society of Japan, a chairman of Power and Energy System Division, JSME, and Dean of Faculty of Engineering Science, Kansai University, from April 2007 to October 2008. He is now an Assembly Member of World Conference on Experimental Heat Transfer, Fluid Mechanics and Secretary General of JSME Kansai Branch. He has published more than 120 articles in major journals and presented more than 120 international conference papers.
	Shaurya Prakash, Rutgers University, USA Presentation Title: High Temperature Microsystems Recent times have seen a growing interest in developing next generation energy systems and devices for building very small engines, power plants, and high temperature microchemical reactors, all running on the combustion of hydrocarbon fuels due to their inherently high energy densities. In particular, much interest lies in creating small-scale fuel reformers to produce hydrogen and/or syngas for fuel cells. Over the past decade, most microscale combustion systems that have been developed employ catalytic and heterogeneous combustion processes. In this presentation, I will discuss the development of sub-millimeter or microscale homogeneous combustion systems operating at high temperatures, which can approach adiabatic flame temperatures, to achieve potentially high power densities (~ 103 W/cm3). I will present results to discuss the role and importance of surfaces in creating and sustaining homogeneous flames in narrow, confined structures with channel dimensions as small as 100 µm. At these length scales, we have also observed some unusual flame structures and flame dynamics that vary strongly with changes in boundary conditions. In this talk, I will present our experimental data, observations of flame structure and dynamics, and discuss several open questions that remain to be answered. A brief biography Shaurya Prakash is an Assistant Professor at the Department of Mechanical & Aerospace Engineering at Rutgers, The State University of New Jersey. He received his Ph.D. in 2007 from the University of Illinois at Urbana-Champaign. His current research interests are in developing microsystems and nanosystems for applications in water purification, alternate and renewable energy, and chemical and biological separations.
	Albert Renken, Institute of Chemical Sciences and Engineering Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland Presentation Title: Micro-Structured Reactors and Catalysts for the Intensification of Chemical Processes Process intensification (PI) is the term which describes an innovative design approach in chemical engineering aiming on miniaturization of chemical reactors and plants. This would decrease the running cost and make process more efficient, safer, and less polluting that the existing ones. PI is often quantified by the significant increase, of at least an order of magnitude, of the ratio of equipment volume to the product yield and decreasing energy consumption. It also lowers the amount of waste and leads to better use of raw materials. Chemical micro-structured reactors (MSR) are devices containing open paths for fluids with dimensions in the sub-millimeter range. Mostly MSR have multiple parallel channels with diameters between ten and several hundred micrometers where the chemical transformations occur. This results in a high specific surface area in the range of 10000 to 50000 m2/m3 and allows an effective mass and heat transfer compared to traditional chemical reactors having usually ~100 m2/m3. Another important feature of MSR is that the heat exchange and the reaction are mostly performed in the same gadget. MSR are operated under laminar flow with the heat transfer coefficient for liquids about 10 kW/(m2·K). This is at least one order of magnitude higher than in traditional heat exchangers allowing: to avoid hot-spot formation, to attain higher reaction temperatures and to reduce reaction volumes. This in turn improves the energy efficiency and reduces the operational cost. An integrated heat exchange makes the key difference between MSR and other structured reactors like honeycombs. Intensification of heterogeneous catalytic processes involves besides of innovative engineering of MSR, the proper design of the catalyst. This requires the simultaneous development of the catalyst and the reactor. The catalyst design should be closely integrated with the reactor design taking into consideration the reaction mechanism, mass-/heat transfer and the energy supply addressing high selectivity/yield of the target product. Besides general criteria for the choice and proper design of micro-structured reactors for process intensification, particular needs for homogeneous and multiphase reactions will be discussed. A brief biography Albert Renken became Professor in Chemical Reaction Engineering at the Swiss Federal Institute of Technology in Lausanne in 1977. His scientific interests are: Heterogeneous catalytic reaction engineering, unsteady-state operation of chemical reactors, structured catalysts, and micro-structured reactors. He is a Swiss delegate in the working party on Chemical Reaction Engineering (Chairman 1996-2003) of the European Federation of Chemical Engineering, and Chairman of the Working Parties of Chemical Reaction Engineering in Germany and Switzerland. AR is member of the European Network of Excellence: “Integrated Design of Catalytic Nanomaterials for a Sustainable Production (IDECAT)”. In 2007 he was awarded with the DECHEMA-Medal for his engagement and pioneering contributions to Chemical Reaction Engineering and Microreaction Technology. He is author/co-author of more than 400 scientific publications, 16 patents and two textbooks in Chemical Reaction Engineering, and co-edited the Handbook of Micro Reactors actually in press. His actual research activities concern the development micro structured reactors for multiphase reactions.
	Gary Rosengarten, University of New South Wales, Australia Presentation Title: Can We Learn from Nature to Design More Efficient Membranes? The Intricate Pore Structure of the Diatom Diatoms are unicellular microscopic algae that live in sea and fresh water. What makes them fascinating is that they have a self-assembled nano-porous silica membrane wall whose function is very poorly understood. They are known however to accept nutrients but reject viruses very efficiently. As membranes are used extensively in a wide variety of applications such as fuel cells and desalination, where the system efficiency is often determined by the membrane performance, membrane designs that are more selective, allow higher permeate fluxes and avoid fouling will have major industrial impacts. I will present our recent work on examining diatoms as model membrane structures. I will outline the methods used to obtain the unique three dimensional structure of the micro and nano-pores including AFM, SEM and 3D image reconstruction. I will also detail our experimental methods using confocal microscopy and fluorescence correlation spectroscopy to, for the first time, determine diffusion coefficients with high resolution (probe volume <1fl) inside diatom pores. The tortuosity is shown to have a major influence on reducing the overall diffusion coefficient in the pores to approximately 50% of that in free solution. A brief biography Gary Rosengarten is a senior lecturer in the School of Mechanical and Manufacturing Engineering at the University of New South Wales, Australia, where he heads the microfluidics and heat transfer groups. He completed honours degrees in Physics and Mechanical Engineering at Monash University, and a Ph.D. at the University of NSW. Prior to his position at UNSW he worked as a consultant engineer, and as a research fellow at the University of Melbourne and RMIT University. He was the winner of the inaugural ASME graduate student award in solar energy in 2000 and the prestigious Victoria fellowship in 2002. His research interests include fluid flow and heat transfer for micro- and nano-systems specifically related to energy and biomedical devices, interfacial effects in microfluidics, and biomimetics- gaining inspiration from nature for engineering design.
	Dusan P. Sekulic, University of Kentucky, USA Presentation Title: Wetting and Spreading of Liquid Metals through Open Micro Grooves and Surface Alteration Surface tension driven flows of micro layers of liquids over substrates under reactive wetting conditions are greatly influenced by topography of surface alterations. Understanding of spreading of molten metals over metal substrates with complex topography may be interpreted as spreading over multiple connected networks of open micro channels. Hence, understanding of the kinetics of wetting and spreading of such reactive systems through micro channels is of a key interest. This key-note lecture will provide an overview of wetting/spreading phenomena related to migration of the molten metal micro layer over smooth, rough, and well-organized-topography surfaces, such as micro channels. Systems involving high temperature range (Ag-Cu over Ti), mid temperature range (Al-Si over Al), and low temperature domains (Ag-Sn over Cu and Cu-Sn) will be considered. Kinetics data involving the triple line movement and its modeling will be supported by real-time in situ visualizations. Targeted applications of these fundamental studies involve art of brazing of compact aluminum heat exchangers for HVAC&R, thermal management for aerospace, and soldering processes (in particular lead-free) for electronics industries. A brief biography Dusan P. Sekulic is a Professor of Mechanical Engineering at the College of Engineering, University of Kentucky, Lexington, USA. Dr. Sekulic is the Director of the Brazing and Heat Exchanger Laboratory at the Center for Manufacturing. Dr. Sekulic is author of over 130 technical publications, numerous book chapters and one book (Fundamentals of Heat Exchanger Design, published by Wiley in 2003, jointly with Dr. R.K. Shah). Dr. Sekulic is an editor of the Heat Exchanger Design Handbook published by Begel House and a member of editorial boards of four international technical journals. Dr. Sekulic is a Fellow of the American Society of Mechanical Engineers.
	Naoki Shikazono, University of Tokyo, Japan Presentation Title: Liquid Film Thickness in Micro Channel Slug Flow Slug flow is one of the representative flow regimes in micro channel two-phase flow. It is known that thin liquid film formed between the channel wall and the vapor bubble plays an important role in micro channel heat and mass transfer. In the present study, experiments are carried out to clarify the effects of parameters that affect the formation of thin liquid film in a micro channel. Laser focus displacement meter and interferometer are used to measure the liquid film thickness. Air, ethanol and water are used as working fluids. Channels with different size and cross sectional shape are used. The effects of capillary number and Reynolds number on dimensionless thin liquid film thickness are investigated. A brief biography Naoki Shikazono received his M.S. and Ph.D. degrees from the University of Tokyo, Mechanical Engineering in 1989 and 1994. After graduation, he worked for Mechanical Engineering Research Laboratory, Hitachi, Ltd. from 1994 to 2002 in the field of air conditioning and refrigeration. Since 2002, he is an Associate Professor at School of Engineering at the University of Tokyo, Japan. His present interests include modeling of Solid Oxide Fuel Cell electrodes and heat and fluid flow for heat engines and heat pumps.
	Shuichi Takayama, University of Michigan, USA Presentation Title: Micro- and Nanofluidics for Cellular Physiology Studies Many biological studies, drug screening methods, and cellular therapies require culture and manipulation of living cells outside of their natural environment in the body. The gap between the cellular microenvironment in vivo and in vitro, however, poses challenges for obtaining physiologically relevant responses from cells used in basic biological studies or drug screens and for drawing out the maximum functional potential from cells used therapeutically. One of the reasons for this gap is because the fluidic environment of mammalian cells in vivo is microscale and dynamic whereas typical in vitro cultures are macroscopic and static. This presentation will give an overview of efforts in our laboratory to develop microfluidic systems that enable spatio-temporal control of both the chemical and fluid mechanical environment of cells. The technologies and methods close the physiology gap to provide biological information otherwise unobtainable and to enhance cellular performance in therapeutic applications. Specific biomedical topics that will be discussed include, in vitro fertilization on a chip, microfluidic tissue engineering of small airway injuries, micropatterned gene delivery and knockdown, and development of tuneable nanofluidic systems towards applications in single molecule DNA analysis. A brief biography Shuichi Takayama is associate professor in the Department of Biomedical Engineering and the Macromolecular Science and Engineering Program at the University of Michigan, Ann Arbor. He received his B.S. and subsequently his M.S. from the University of Tokyo in 1994 and his Ph.D. degree in chemistry from the Scripps Research Institute in 1998, after which he did postdoctoral studies at Harvard University as a Leukemia and Lymphoma Society postdoctoral fellow. He joined the faculty of the Department of Biomedical Engineering at the University of Michigan, Ann Arbor, in the fall of 2000. His current research interests are: Micro- and Nanofluidics, Biomaterials and Surface Engineering, Microscale tissue engineering, and study of how Cellular Microenvironments affect cell behavior. Honors include Leukemia and Lymphoma Society Fellow (1998-2001), Whitaker Foundation Biomedical Engineering Research Award (2001), The Ralph E. Powe Junior Faculty Award (ORAU, 2002), The NSF Career Award (NSF, 2003), advisor award for The Collegiate Inventors Competition (USPTO, 2004), and the Biomedical Engineering Department Award for Outstanding Accomplishment (UM CoE, 2006).
	Osama Tonomura, University Kyoto, Japan Presentation Title: Model-Based Shape Design and Fault Diagnosis for Microreactors In microspaces, viscous force, surface tension, conduction heat transfer, and molecular diffusion become dominant. These features achievable in microspaces make it possible to handle highly exothermic and rapid reactions and to produce fine particles with narrow size distribution. The goal of our research is to develop a fundamental approach to design, operation, and control of microreactors. Now, we are conducting researches into modeling and simulation for microreactor design. In addition, we are developing a model-based process monitoring system which is applicable for diagnosing faults such as blockage in microreactors. A brief biography Osamu Tonomura is currently an Assistant Professor in the Department of Chemical Engineering at Kyoto University, Japan. His major research interests include the modeling, design, and process monitoring of micro chemical plants. He has over 50 publications (journal, conference papers, and book chapters) and two micro chemical process related patents. He is member of The Society of Chemical Engineers, Japan (SCEJ) and American Institute of Chemical Engineers (AIChE).
	Fan-Gang Tseng, National Tsing Hua University, Hsinchu, Taiwan Presentation Title: From High Performance Protein Micro Chip Toward Ultra High Sensitive Single Molecule Nano Array Protein microarrays have been employed to screen tens to thousands of proteins simultaneously for the observation of the biochemical activities in the protein-protein, protein-nucleic acid and small molecule interactions. This technology allows high throughput analysis and holds great potential for basic molecular biology research, disease marker identification, toxicological response profiling and pharmaceutical target screening. However, proteins easily malfunction in harsh environments so that they are hardly preserved before the application because of their complex and fragile structures. On the other hand, identify scarce amount of proteins less than fM range is very important and challenge for disease diagnosis at very early stage. As a result, the procedures for protein micro array formation are very important for preserving protein functionality to ensure useful protein assays, as well as the improvement of the detection sensitivity up to single molecule event but with high dynamic range for disease early detection. Therefore, this presentation provides a novel view from the preparation of high efficient protein micro chip toward ultra high sensitive single protein molecule array through the technology integration of BioMEMS and Bio-Nanotechnology. In the high efficient and rapid preparation of protein micro array, micro contact printing system with batch-filling and parallel-printing capability was employed for rapid generation of protein micro arrays. This system provides a passive, gentle, and high throughput way to simultaneously filling and printing tens to thousands of bio-solutions in seconds into a dense array for disease diagnosis or drug screening. To further improve the detection sensitivity and protein recognition efficiency, gas type nano-bio blocking agent and nano patterned protein binding site were carried out, and two orders of magnitude signal enhancement has been successfully demonstrated. On the other hand, to enhance the signal into single molecule level detection, a novel nano-cone single molecule detection site was proposed and implemented. This patented binding site can accommodate only one protein molecule at a time, and allow very low background noise for the detection of single molecule event. The excitation/detection volume can be reduced into less than sub-aL range (~20-50 nm in diameter), an extremely localized excitation to greatly reduce background noise. On the other hand, the dynamic range of the applicable substrate concentrations can be enlarged by localized sample concentration techniques combining the actions of surface tension gradient and AC electro-osmosis flow. As a result, the detection of substrate concentration from 1 fM (~1-10 molecules/10000 µm2) to 1 µM is feasible, allowing a 6-9 orders of magnitude of dynamic range. A brief biography Fan-Gang Tseng received his Ph.D. degree in mechanical engineering from the University of California, Los Angeles, USA (UCLA), under the supervision of Prof. C.-M. Ho and C.-J. Kim in 1998. After one year with USC/Information Science Institute as a senior engineer working on a new microfabrication process, EFAB, he became an assistant professor with Engineering and System Science Department of National Tsing-Hua University, Taiwan from August, 1999, and was advanced to associate professor in August, 2002, as well as professor in August 2006. His research interests are in the fields of Bio-MEMS/Bio-Nano and Nano/Micro-Fluidic Systems. He received 19 patents, wrote 4 book chapters including "Micro Droplet Generators" in MEMS Handbook by CRC press and "Technological Aspects of Protein Microarrays and Nanoarrays" in Protein Microarrays by Jones and Bartlett Publishers, published more than 80 SCI Journal papers, and 160 conference technical papers in MEMS, Bio-N/MEMS, and micro/nano fluidics related fields, and served as the technique committee member as well as co-chair in many international conferences including IEEE NANOMED07, IEEE NANO07, APCOT06, IEEE NEMS 06, ROBIO 2005, ISMNT 06, IS3M 00, and IEEE Transducers'01 and the reviewer for more than 15 SCI cited journals. He received several awards, including Mr. Wu, Da-Yo Memorial Award from National Science Council, Taiwan (2005-2008), four best paper/poster awards (1991, 2003, 2004, and 2005), NTHU new faculty research award (2002), NTHU outstanding teaching award (2002), NTHU academic booster award (2001), and NSC research award (2000).
	Steven Wereley, Purdue University, USA Presentation Title: Optoelectric Micro/Nano Particle Manipulation Recently our research group has developed an innovative method for capturing, concentrating, manipulating and sorting populations of particles ranging from single particles to thousands of particles (Lab-on-a-Chip, 2008; Microfluidics and Nanofluidics, 2008). This novel technique uses a simple parallel plate electrode configuration. Transparent electrodes comprised of Indium Tin Oxide (ITO) on glass substrates were used to generate an electric field in the fluid but also to allow light into and out of the fluid. Near-IR optical illumination causes subtle localized heating, creating an electric permittivity gradient that in turn drives a microscopic toroidal vortex. The vortex efficiently transports particles to a preferred location, usually the surface of the electrode. The flow velocity is characterized as a function of the AC signal frequency and the strength of electric field using conventional microscopic imaging along with micro particle image velocimetry (PIV). PIV measures the velocity of a flow by tracking the motion of sub-micron tracer particles carried by the flow. To measure high velocity, small length scale flows, high speed lasers and interline transfer CCDs are used in conjunction with a microscope to image the tracer particles with sub-microsecond temporal resolution. The application of this technique to several typical micro systems, including the optoelectric vortex described earlier, will be presented and the results discussed. Recent trends in PIV have allowed the spatial resolution of the technique to be increased such that even sub-micron domains can be measured in a spatially resolved manner. A brief biography Professor Wereley completed his masters and doctoral research at Northwestern University studying Taylor-Couette flows as filtration aids. He joined the Purdue University faculty in August of 1999 after a two-year postdoctoral appointment at the University of California Santa Barbara. During his time at UCSB he focused exclusively on developing diagnostic techniques for microscale fluid systems, work which ultimately led to developing, patenting, and licensing to TSI, Inc., the micro-Particle Image Velocimetry technique. His current research interests include designing and testing microfluidic MEMS devices, investigating biological flows at the cellular level, improving micro-scale laminar mixing, and developing new micro/nano flow diagnostic techniques. Professor Wereley is very active in the field of micro/nanoscale fluid mechanics, delivering invited lectures, short courses and consulting, in addition to performing scholarly research in the area. Professor Wereley is the co-author of Fundamentals and Applications of Microfluidics (Artech House, 2002 and 2006) and Particle Image Velocimetry: A Practical Guide (Springer, 2007). He is on the editorial board of Microfluidics and Nanofluidics Journal and Experiments in Fluids and is an Associate Editor of ASME’s Journal of Fluids Engineering. Professor Wereley has edited Springer’s recent Encyclopedia of Microfluidics and Nanofluidics and Kluwer’s BioMEMS and Biomedical Nanotechnology.
	Y.-M. Xuan, Nanjing University of Science & Technology, China Presentation Title: Energy Transport Mechanisms in Nanofluids and its Applications Nanofluid is a solid-liquid mixture consisting of solid nanoparticles or nanofibers with sizes typically of 1-100 nm suspended in liquid. A number of fundamental phenomena and mechanisms concerned in possible applications of the nanofluids to thermo-science and thermal engineering were investigated in the present paper. The following main problems are discussed: (1) Microscopic and mesoscaled approaches for the heat transfer enhancement mechanism of the nanofluid. (2) Flow and heat transfer mechanism and the relevant control methods of the magnetic fluid in the presence of an external magnetic field. (3) Some applications of nanofluid on a variety of thermal systems. With respect to the stochastic motion and thermal transport of the suspended nanoparticles, the present article analyzes the thermal transport process between the nanoparticles and the carrier liquid. Being based on the superposition principle and the Green-Kubo theorem, a model for the effective thermal conductivity of the nanofluid is proposed. The mechanism of enhanced thermal conductivity of the nanofluid was analyzed at the microscopic level. The lattice-Boltzmann models have been established for simulating dynamic flow and energy transport of nanofluids in order to investigate flow and heat transport mechanism inside the nanofluid at the mesoscaled level. A number of external and internal forces acting on the suspended nanoparticles and interactions among the nanoparticles and liquid particles as well as the heat exchange between the nanoparticles and the liquid have been taken into account in the models. The models provide ones with the tool for studying the interactions among the nanoparticles’ motion, the nanofluid morphology, and flow and energy transport of nanofluids at the mesoscopic level. With respect to the unique thermomagnetic features of the magnetic fluid, research efforts were put on the thermal properties and energy transport performance of the magnetic fluid under the influence of an external magnetic field to develop the relevant approaches for control such processes. The effects of the external magnetic field strength and its orientation on the thermal behaviors of the magnetic fluids were analyzed. The results show that the external magnetic field is a vital factor that affects the energy transport features of the magnetic fluids and the control of heat transfer processes of a magnetic fluid flow can be possible by applying an external magnetic field. By means of some temperature-sensitive magnetic fluids, the automatic energy transport principles as well as some structures of the magnetic fluids were studied. The flow and heat transport features of the device were experimentally examined in order to get insight into the mechanism and controlling approaches for such an automatic operation device. The constitutive thermal, magnetic and fluid dynamic relationships of the automatic energy transport device were discussed. The investigation has shown that by adjusting the external magnetic field and/or temperature gradient field inside the magnetic fluid, one can control the energy transport process of such devices. Several exploratory studies concerning possible applications of nanofluids have also been carried out, including electronics cooling and thermal management of spacecraft. Flow and thermal performances of nanofluids flowing through miniature and/or microscaled channels have been experimentally measured. Jet impingement cooling using the nanofluid as the working fluid has been studied. By means of suspending the nanoparticles into some coolants with poor thermal conductivity which are originally used for spacecraft cooling systems, the thermal behaviours of such heat carrier have been experimentally investigated. The investigations have shown that nanofluids can remarkably improve heat transfer effectiveness of the heat transfer system. A brief biography Professor Yimin Xuan is currently a Professor at Nanjing University of Science & technology, CHINA. He received his Ph.D. degree in Heat Transfer and Energy Engineering in 1991 from University of the Federal Armed Forces Hamburg, Germany. Professor Xuan has published more than 150 technical papers. His research interests mainly include: (1) Fundamentals for enhancing heat transfer and their engineering applications; (2) Cooling techniques for electronic devices and equipment; (3)Development and optimization of heat exchangers with high efficiency; (4) Thermal management in aerospace and aeronautical engineering; and (5) Sustainable New energy and efficient-application technology of energy.
	Yuying (Y.Y.) Yan, University of Nottingham, UK Presentation Title: Micro/Meso Scope Modelling Of Two-Phase Flow on Hydrophilic/Hydrophobic Surfaces - A Simulation of Natural Hydrophobic Surfaces With Micro Roughness The talk starts from a brief review of the micro roughness surface structures of natural functional surfaces with hydrophobic and self cleaning characteristics, and then follows a short overview of its visible or possible applications in engineering. To focus on the biomimetic approaches of such natural hydrophobic surfaces, the physical model for reaching the physics similarity between the natural surfaces and those for the designs in engineering applications is discussed. The physical model is basically a problem of two-phase flow interacting with the surfaces. To solve such complex two-phase flow behaviour involving surface wettability, a numerical modelling based on the micro/meso scope lattice Boltzmann method (LBM) has been developed and applied to the numerical calculation and simulation. The LBM modelling deals with surface tension dominated behaviour of water droplets in air spreading on a hydrophilic surface with hydrophobic strips of different sizes and contact angles under different physical and interfacial conditions, and aims to find quantitative evidence and physical conditions of the biomimetic approaches. The current lattice Boltzmann method (LBM) can be applied to simulate two-phase fluids with large density ratio (up to 1000), and meanwhile deal with interactions between a fluid-fluid interface and a partial wetting wall. The modelling and simulation are effective and successful. In the simulations, the interactions between the fluid-fluid interface and the partial wetting wall of different hydrophobic strips namely the single strip, intersecting stripes, and alternating & parallel stripes, of different sizes and contact angles are considered and tested numerically; the phenomena of droplets spreading and breaking up, and the effect of hydrophobic strips on the surface wettability or self-cleaning characteristics are simulated and reported. A brief biography Yuying Yan is an Associate Professor and Research Team Leader of Thermofluids & Modelling in School of the Built Environment at the University of Nottingham. He was awarded PhD in Mechanical Engineering at City University (London) in 1996 and was a research fellow of two-phase flow in Department of Chemical & Process Engineering at University Surrey (UK) (1996-1998). He was appointed to an academic position as a senior lecturer in Mechanical Engineering at Nottingham Trent University in 1998, then be promoted to Reader in Thermofluids in 2003. He has moved to the University of Nottingham with his current permanent appointment since 2004. Dr Yan’s current research interests include multi scales modelling of microchannel flow boiling, biomimetics of functional surfaces with fluids interactions, and efficient cooling technology. His research has been supported by the UK Engineering Physical Science Research Council (EPSRC) and Royal Society. He has authored/co-authored more than 100 papers including 50 refereed journal articles. He has been awarded guest professorship by two prestigious Chinese universities (Jilin University and Dalian University of Technology) since 2004, and acted as the UK coordinator of UK-China joint laboratory of Biomimetics on functional surfaces of fluids interactions since 2008.
	Chien-Yuh Yang, National Central University, Taiwan Presentation Title: Development of a Miniature Liquid Cooling System for High Heat Flux Electronic Devices The size of the most of the current commercialized liquid cooling systems is apparently too large to be easily adapted in a notebook or a mini size desk top computer. This study incorporated the authors' previous micro heat exchanger design with an extra slim pump concept proposed by a local manufacturer to develop a high performance miniature liquid cooling system. The size of the integrated pump and cold plate module is less than one tenth of the commercial products. The overall hear transfer performance has been tested for cooling load from 100 W to 250 W. The results show that the heating center to air thermal resistance is in the range of 0.13 to 0.14 oC/W which is less than 2/3 of other commercial systems tested. A brief biography Chien-Yuh Yang is currently a professor of Department of Mechanical Engineering at the National Central University, Taiwan. He received his PhD from the Pennsylvania State University in 1994, and then joined the National Central University in 1995. His current research interests include heat exchanger design, two-phase heat transfer, heat transfer enhancement, micro-scale heat transfer and electronic devices thermal management. He has published more than 50 academic papers, one textbook and more than ten micro heat exchanger related patents. Several items of his research results have been technically transferred to industry and applied for commercialized products.
	Jun-Ichi Yoshida, University Kyoto, Japan Presentation Title: Flash Chemistry: Fast Chemical Synthesis In Micro Flow Systems Because of rapid progress in organic synthesis, demands for producing desired compounds in a highly time-efficient way have been increasing. In order to meet such demands and achieve fast synthesis of a variety of organic compounds, acceleration of organic reactions is highly sought after. Chemists have used slow reactions because fast reactions are difficult to control and often give significant amounts of undesired by-products. Reaction time in conventional organic synthesis usually ranges from minutes to hours. In order to achieve faster synthesis, the use of much faster reactions in a controlled way is highly desirable. This presentation provides a brief outline of the concept of flash chemistry for conducting extremely fast reactions in a highly controlled manner for organic synthesis using microflow systems. In flash chemistry, reaction time ranges from milliseconds to seconds. A brief biography Jun-ichi Yoshida was born in Osaka, Japan in 1952. He graduated from Kyoto University in 1975, where he received his doctor's degree under the supervision of Prof. Makoto Kumada in 1981. In 1979 Yoshida joined the faculty at Kyoto Institute of Technology as an assistant professor. In the meantime, he visited University of Wisconsin during 1982-1983, where he joined the research group of Prof. B. M. Trost. In 1985 he moved to Osaka City University, where he was promoted to an associate professor in 1992. In 1994 he was appointed as a full professor of Kyoto University. His research interests include integrated organic synthesis on the basis of reactive intermediates, organic electron transfer reactions, organometallic reactions, and microreactors. Awards: the Progress Award of Synthetic Organic Chemistry, Japan (1987), the Chemical Society of Japan Award for Creative Work (2001), Nagoya Silver Medal of Organic Chemistry (2006), and Humboldt Research Award (2007).