Presentation Title: The Use of Neuromodulation Technology in the Non-Invasive Treatment of Pain and other Disease Conditions

Leon M. Silverstone obtained his sciences and pre-medical education at Queen Mary College, University of London, UK, and his professional degrees from The Royal College of Surgeons of England, and the University of Leeds School of Dental Surgery. He obtained his Ph.D. in pathology from the University of Bristol, UK, and then became the first recipient of the D.D.Sc. degree by thesis from the University of Leeds for his work on experimental remineralization. He was a Reader and Hospital Consultant at The Royal London Hospital Medical College, and in 1976 left the UK for the U.S. where he held appointments as Professor and Head of the first Division of Cariology in the U.S. at the Dows Institute for Dental Research, University of Iowa Health Sciences Center in Iowa City, followed by Associate Dean for Research at the University of Colorado Health Sciences Center. In 1989, after 26 years in full-time academia, he joined the private sector where his research has focused on device development for treatment of pain and other disorders.

In 1971 he was the recipient of the First International Research Award of the Nobel- Pharma A. B. Bofors Prize presented in Copenhagen, Denmark. In 1973 The European Organization for Caries Research awarded him the ORCA-Rolex Research Prize in Zurich, Switzerland. In 1984 he received the Distinguished Scientist Award from the International Association for Dental Research. His scientific biography appears in the Who’s Who in the World; his editorial experience includes editor, editorial board member, and reviewer for a range of medical and scientific journals. He has worked with the Medical Research Councils of Great Britain and Canada, and the Pan American Health Organization (PAHO) branch of the World Health Organization (WHO), carrying out field assignments for PAHO in Latin America and the Caribbean. He is past President of the European Organization for Caries Research and the first to be appointed from the U.S. He is a past member of the Oral Biology and Medicine Study Section (grant review committee) of the National Institutes of Health (NIH), the Small Business Innovative Research Committee (SBIR), and past Chairman of the NIDR Programs Advisory Committee (PAC) at NIH. He has authored 360 scientific publications, made many television, appearances and lectured by invitation worldwide.

His research commenced in 1964 and has been involved with etiology, pathology and prevention of diseases in oral hard tissues, development of synthetic remineralizing fluids to physico-chemically repair demineralized tissues, and investigation of pain syndromes and neuro-degenerative diseases. In the 1980’s he developed the UltraCalm^® device for noninvasive dental anesthesia (no needles), followed by the Synaptic^® series of devices for treatment of acute and chronic pain syndromes. Over the past decade his efforts have been directed to treatment devices for sleep & memory problems, clinical tremor, depression, and neuro-degenerative diseases. He has also developed novel devices for viral diseases such as genital herpes, all of which are based on non-invasive brain neuromodulation. His patents over the past two decades reflect this body of work.